Our Science

Quality, and quantity.

Most fertility supplements use cheaper, less absorbable synthetic forms of the nutrients that matter. Most also use doses too low to do what the research recommends. We think that is wrong.

Every BioMirco formulation is informed by published research on the individual nutrients we use. Research on cellular energy, cell division, hormone regulation, blood formation, and maternal nutrition. Across the 26 nutrients in Fertility Advance and Focus, the cumulative research pool spans more than 500 peer-reviewed studies and research papers.

Our formulations are built with practising fertility nutritionists, in active collaboration with the broader fertility community we have been part of for twelve plus years. We review our formulations annually, and update them when new research recommends.

We do not run our own clinical trials. We build around the trials that already exist.

Every nutrient. Every authorised health claim.

Each ingredient in BioMirco Fertility Advance and Focus, with the GB Authorised Health Claims that apply. Where a fertility-specific claim is not yet authorised, we mark it as active research.

Jump to: Folate · Vitamin B12 · Coenzyme Q10 · Zinc · Selenium · Iodine · Choline · Vitamin B6 · Vitamin D3 · Vitamin C · Vitamin E · Vitamin K2 · B5 · B1 · B2 · B3 · Biotin · Beta-carotene · Ginger Root Extract · Calcium · Manganese · Copper · Chromium · Molybdenum · Boron

Folate (5-MTHF Calcium)

• Folate contributes to maternal tissue growth during pregnancy.
• Folate has a role in the process of cell division.
• Folate contributes to normal amino acid synthesis, normal blood formation and normal homocysteine metabolism.

Vitamin B12 (Methylcobalamin + Adenosylcobalamin)

• Vitamin B12 contributes to normal red blood cell formation.
• Vitamin B12 contributes to normal energy-yielding metabolism.
• Vitamin B12 contributes to normal homocysteine metabolism.

Coenzyme Q10 (Natural Ubiquinone)

Coenzyme Q10 is naturally present in cellular mitochondria. Its role in oocyte energy metabolism has been examined in research including Bentov et al. (2014) in the Journal of Assisted Reproduction and Genetics and Ben-Meir et al. (2015) in Aging Cell. Fertility Advance includes 300mg of natural ubiquinone CoQ10 per daily dose; Fertility Focus includes 200mg.

Zinc (Picolinate)

• Zinc contributes to normal fertility and reproduction.
• Zinc contributes to normal DNA synthesis.
• Zinc has a role in the process of cell division.

Selenium (Selenium Yeast)

• Selenium contributes to normal spermatogenesis.
• Selenium contributes to the protection of cells from oxidative stress.

Iodine (Potassium Iodide)

• Iodine contributes to normal thyroid function.
• Iodine contributes to normal cognitive function.

Choline (L-Bitartrate)

• Choline contributes to normal homocysteine metabolism.
• Choline contributes to normal lipid metabolism.
• Choline contributes to the maintenance of normal liver function.

Vitamin B6 (Pyridoxine HCl)

• Vitamin B6 contributes to the regulation of hormonal activity.
• Vitamin B6 contributes to normal energy-yielding metabolism and normal red blood cell formation.

Vitamin D3 (vegan, lichen-source)

• Vitamin D has a role in the process of cell division.
• Vitamin D contributes to normal function of the immune system.

Vitamin C (Calcium Ascorbate)

• Vitamin C contributes to the protection of cells from oxidative stress.
• Vitamin C contributes to normal collagen formation.
• Vitamin C increases iron absorption.

Vitamin E (Natural D-Alpha Tocopherol Succinate)

Vitamin E contributes to the protection of cells from oxidative stress.

Vitamin K2 (MK-7)

• Vitamin K contributes to normal blood clotting.

B5 (Calcium Pantothenate / Pantothenic Acid)

• Pantothenic acid contributes to normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters.

B1 (Thiamine HCl)

• Thiamine contributes to normal energy-yielding metabolism.

B2 (Riboflavin)

• Riboflavin contributes to normal energy-yielding metabolism.

B3 (Niacin / Nicotinic Acid)

• Niacin contributes to normal energy-yielding metabolism.
• Niacin contributes to normal functioning of the nervous system and normal psychological function.

Biotin

• Biotin contributes to normal energy-yielding metabolism.

Beta-carotene (from Dunaliella salina algae)

Provides natural vitamin A activity through cellular conversion.

Ginger Root Extract (20:1, 5% gingerols)

Traditional botanical, included for digestive comfort during preconception.

Calcium (Citrate)

• Calcium contributes to normal energy-yielding metabolism and normal muscle function.

Manganese (Citrate)

• Manganese contributes to normal energy-yielding metabolism.

Copper (Citrate)

• Copper contributes to normal energy-yielding metabolism.

Chromium (Picolinate)

• Chromium contributes to normal macronutrient metabolism.

Molybdenum (Ammonium)

Molybdenum contributes to normal sulphur amino acid metabolism.

Boron (Sodium Borate)

Boron is included for its role in trace mineral balance.

5-MTHF Folate

Up to 40% of women carry a variant in the MTHFR gene that reduces their ability to convert synthetic folic acid into the active form their body uses. We skip the conversion step entirely.

Every BioMirco formula uses 5-MTHF Calcium. The already-active form of folate, usable by 100% of women regardless of MTHFR status. Fertility Advance contains 800µg per daily serving. Fertility Focus contains 533µg, calibrated to support first-trimester requirements.

Two active forms of B12

Cheap supplements use cyanocobalamin, a synthetic form your body has to convert. We use both methylcobalamin (which supports nervous system function and homocysteine metabolism) and adenosylcobalamin (which is involved in mitochondrial energy production). Both are already in their active forms.

Fertility Advance contains 750µg total B12. Fertility Focus contains 500µg.

Six papers worth knowing

Vitamin D status and IVF outcomes

Chu et al. 2018. Human Reproduction.

Women replete in vitamin D had significantly higher live birth rates after assisted reproductive treatment.

CoQ10 pretreatment in low-prognosis IVF

Xu et al. 2018. Reproductive Biology and Endocrinology.

CoQ10 pretreatment improved ovarian response, oocyte and embryo quality in low-prognosis women undergoing IVF.

Folate, B12 and follicular fluid homocysteine

Boxmeer et al. 2008. Fertility and Sterility.

Higher follicular folate and lower homocysteine were associated with improved oocyte quality and embryo development.

Selenium status and male fertility

Mistry et al. 2012. Reproductive Sciences.

Selenium status correlates with semen quality. Selenium contributes to normal spermatogenesis.

MTHFR variants and folate metabolism

Patanwala et al. 2014. American Journal of Clinical Nutrition.

5-MTHF achieved equivalent or superior plasma folate response to folic acid, regardless of MTHFR genotype.

Zinc status in male and female fertility

Garner et al. 2018. Reproductive Toxicology.

Zinc is critical for normal sperm development and oocyte maturation. Zinc contributes to normal fertility and reproduction.

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The 500+ study count refers to the cumulative body of peer-reviewed research on the individual nutrients in BioMirco formulas (PubMed-indexed), relating to the ingredients themselves and their broader health relationships. Studies are not specific to BioMirco products. Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle.